Journal of the Chemical Society. Perkin transactions I p. 859 - 863 (1996)
Update date:2022-08-17
Topics:
Pettit, George R.
Srirangam, Jayaram K.
Singh, Sheo Bux
Williams, Michael D.
Herald, Delbert L.
Barkoczy, Jozsef
Kantoci, Darko
Hogan, Fiona
Total synthesis of the extraordinary antineoplastic constituent, dolastatin 10, from the Indian Ocean mollusc Dolabella auricularia has been summarized. The final synthetic step involved diethyl cyanophosphonate-mediated coupling of Dov-Val-Dil with Dap-Doe. Improved syntheses of these important precursors has led to a very practical synthesis of natural dolastatin 10. Important details of the HPLC and high-field (500 MHz) NMR characterization techniques employed to confirm the purity of dolastatin 10 have been recorded. Copyright 1996 by the Royal Society of Chemistry.
View MoreJiangxi Lanqi Fine Chemical S&T Co., Ltd.
Contact:+86-21-64891143
Address:XinJiShan Industrial Area, Zhangshu City, JiangXi Province, China
Wuxi Morality Chemical Co., Ltd(expird)
Contact:
Address:B/7F, 321th WuYun Rd, Wanda Plaza, Wuxi City, 214174, China
website:http://www.maisonchem.com.cn
Contact:0086-311-83833777
Address:Leitou industrial district, xinji, shijiazhuang city, hebei province,
Weifang Ocean Trading Co., Ltd.
Contact:+86-536-2081155
Address:Room2606, Yuqing Building, 518#, Yuquan Road, High-tech Development Zone, Weifang City, Shandong Province, China
Shanghai Norky Pharmaceutical Co., LTD.
website:http://www.norkypharm.com
Contact:86-21-61075300
Address:1165 Jiangning Road, Office 1502, Shanghai, China
Doi:10.1126/science.138.3537.136
(1962)Doi:10.1080/07328303.2011.605193
(2011)Doi:10.1021/acs.inorgchem.5b01938
(2015)Doi:10.1002/chem.201705531
(2018)Doi:10.1039/jr9430000326
(1943)Doi:10.1016/j.jphotochem.2021.113218
(2021)
