Substrate related O,O-dialkyldipeptidylaminophosphonates, a new type of thrombin inhibitor

Article abstract of DOI:10.1080/10426509608545208

The facile reduction of O,O-dialkyl 1-hydroxyiminoalkanephosphonate precursors, using LiBH₄/Me₃SiCl in THF at ambient temperature, conveniently affords O,O-dialkyl 1-aminoalkanephosphonates in good yield and high state of purity. O,O

Full text of DOI:10.1080/10426509608545208

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Phosphorus, Sulfur, and Silicon and
the Related Elements
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Substrate Related O,O-
Dialkyldipeptidylaminophosphonates,
A New Type of Thrombin Inhibitor
Donovan Green , Geeta Patel , Said Elgendy , Jehan
A. Baban , Emmanuel Skordalakes , Wahid Husman ,
Christopher A. Goodwin , Michael F. Scully , Vijay V.
Kakkar & John Deadman
a Thrombosis Research Institute, Emmanuel Kaye Building ,
1B Manresa Road, Chelsea, London S.W.3 6LR, U.K.
b Thrombosis Research Institute, Emmanuel Kaye Building ,
1B Manresa Road, Chelsea, London S.W.3 6LR, U.K.
c Thrombosis Research Institute, Emmanuel Kaye Building ,
1B Manresa Road, Chelsea, London S.W.3 6LR, U.K.
d Thrombosis Research Institute, Emmanuel Kaye Building ,
1B Manresa Road, Chelsea, London S.W.3 6LR, U.K.
e Thrombosis Research Institute, Emmanuel Kaye Building ,
1B Manresa Road, Chelsea, London S.W.3 6LR, U.K.
f Thrombosis Research Institute, Emmanuel Kaye Building ,
1B Manresa Road, Chelsea, London S.W.3 6LR, U.K.
g Thrombosis Research Institute, Emmanuel Kaye Building ,
1B Manresa Road, Chelsea, London S.W.3 6LR, U.K.
h Thrombosis Research Institute, Emmanuel Kaye Building ,
1B Manresa Road, Chelsea, London S.W.3 6LR, U.K.
i Thrombosis Research Institute, Emmanuel Kaye Building ,
1B Manresa Road, Chelsea, London S.W.3 6LR, U.K.
j Thrombosis Research Institute, Emmanuel Kaye Building ,
1B Manresa Road, Chelsea, London S.W.3 6LR, U.K.
Published online: 06 Aug 2008.
To cite this article: Donovan Green , Geeta Patel , Said Elgendy , Jehan A.
Baban , Emmanuel Skordalakes , Wahid Husman , Christopher A. Goodwin ,
Michael F. Scully , Vijay V. Kakkar & John Deadman (1996) Substrate Related O,O-
Dialkyldipeptidylaminophosphonates, A New Type of Thrombin Inhibitor, Phosphorus, Sulfur,
and Silicon and the Related Elements, 109:1-4, 533-536, DOI: 10.1080/10426509608545208

To link to this article: http://dx.doi.org/10.1080/10426509608545208
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