An Optical Resolution of Pyridyl and Bipyridylethanols and A Facile Preparation of Optically Pure Oligopyridines

Article abstract of DOI:10.1016/0040-4039(94)80025-1

A kinetic resolution of racemic pyridyl and bipyridylethanols was performed by Candida antarctica lipase with vinyl acetate in diisopropyl ether, in which (R)-alcohol was acetylated stereoselectively, and both the acetate 2 and the remaining (S)-alcohol 1 were obtained with high enantiomeric excesses. (S)-Oligopyridylethanols, 7 and 8 were prepared by a coupling reaction of (S)-1b and (S)-1e with ethyl bipyridyl sulfoxide.