Catalytic osmylation of allenic compounds. Synthesis of α-hydroxyketo amino acid precursors

Article abstract of DOI:10.1016/0040-4039(96)00571-0

Osmium tetroxyde-catalyzed dihydroxylation of allenic compounds in the presence of N-Methylmorpholine Oxide leads to α-ketols. Regioselectivity of this oxidation procedure with allenic α-amino acid precursors is greatly influenced by the nature and the remoteness of the protected amino acid group.