Selective Oxidation of Optically Active sec,sec-1,2-Diols by Dioxiranes. A Practical Method for the Synthesis of Homochiral α-Hydroxy Ketones in High Optical Purity

Article abstract of DOI:10.1021/jo00066a002

By employing either dimethyldioxirane or its trifluoromethyl analog, the direct, high-yield conversion of one cyclic and three open chain optically sec,sec-1,2-diols to the corresponding α-hydroxy ketones in high optical yield has been achieved.