Heterocycles p. 2041 - 2043 (1997)
Update date:2022-08-16
Topics:
Kim, Moohi Yoo
Lim, Geun Jho
Lim, Joong In
Kim, Dong Sung
Kim, Ik Yon
Yang, Jae Sung
An efficient and practical two-step synthesis of ondansetron (1) was accomplished from readily available N-methyltetrahydrocarbazolone (2) via direct Mannich a-methylenation and alumina catalyzed Michael addition resulting in a 70% overall yield.
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Doi:10.1080/00397911.2011.609303
(2013)Doi:10.1021/jm800608s
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(1970)Doi:10.1039/c9tb02102g
(2020)Doi:10.1016/S0040-4039(02)02312-2
(2002)Doi:10.1007/BF02251796
(1999)
