Cascade Multiple Diels-Alder Reactions of Styrene Derivatives with Maleimide or Maleic Anhydride

Article abstract of DOI:10.1021/acs.joc.8b00890

We developed novel one-pot multiple Diels-Alder reactions, which are frequently used in the construction of six-membered rings in functional molecular synthesis. We report triple and double Diels-Alder reactions with styrene derivatives, where the secondary Diels-Alder reaction takes place at a different position from that of the conventional Wagner-Jauregg reaction.

Full text of DOI:10.1021/acs.joc.8b00890

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Article
Cascade Multiple Diels–Alder Reactions of Styrene
Derivatives with Maleimide or Maleic Anhydride
Shohei YOSHIOKA, Hiroshi Aoyama, Hiromichi Fujioka, and Mitsuhiro Arisawa
J. Org. Chem., Just Accepted Manuscript • DOI: 10.1021/acs.joc.8b00890 • Publication Date (Web): 18 May 2018
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Cascade Multiple Diels–Alder Reactions of Styrene Derivatives with Maleimide or Maleic
Anhydride
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Shohei Yoshioka, Hiroshi Aoyama, Hiromichi Fujioka, Mitsuhiro Arisawa*
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Graduate School of Pharmaceutical Sciences, Osaka University, Yamada-oka 1-6, Suita, Osaka
565-0871, Japan.
*arisaw@phs.osaka-u.ac.jp
Abstract
We developed novel one-pot multiple Diels–Alder reactions, which are frequently used in the
construction of six-membered rings in functional molecular synthesis. We report triple and
double Diels–Alder reactions with styrene derivatives, where the secondary Diels–Alder
reaction takes place at a different position from that of the conventional Wagner-Jauregg
reaction.
Keywords
pericyclic reaction, Diels–Alder reaction, theoretical calculation
Introduction
The Diels–Alder reaction is a reaction between a conjugated diene and an olefin to form the
corresponding substituted cyclohexene, which was developed by Diels and Alder in 1928
(Scheme 1, eq. 1) and is now generally and widely used to synthesize structurally complex
1
molecules, such as biologically active natural products. The Wagner-Jauregg reaction is a
double Diels–Alder reaction of two equivalents of maleic anhydride with one equivalent of
1,1-diarylethylene, which was reported by Wagner-Jauregg in 1930 but is rarely used in
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organic synthesis (Scheme 1, eq. 2). Over 90 years, there have been only four reports based on
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the Wagner-Jauregg reaction.
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Scheme 1. Research background and this work.
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• Diels-Alder reaction (1928)
O
O
7
8
9
(1)
(2)
+
O
O
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O
O
• Wagner-Jauregg reaction, double Diels-Alder reaction (1930)
O
Ph
Ph
O
O
+
2
O
O
O
O
O
O
Ph
• This work 1; triple Diels-Alder reaction
O
O
N
O
O
N Ph
(3)
+
3
NPh
O
X
O
X
O
1; X = silicon, carbon, nitrogen
N
O
Ph
• This work 2; new type double Diels-Alder reaction
Ph
O
N
O
NPh
O
O
(4)
+
NPh
2
X
O
O
X
2; X = silicon, carbon
Performing multiple reactions in one-pot is a useful ability for synthetic organic chemists, and
can minimize solvent usage, time, and the number of purification steps compared with
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individual multi-step syntheses. Although multiple Diels–Alder reactions could offer an
effective approach to polycyclic compounds with six-membered rings, currently there have
been relatively few reports of multiple Diels–Alder reactions. Several examples of triple Diels–
5, 6
Alder reactions exist in addition to the above the Wagner-Jauregg reaction.
We envisioned that the triple Diels–Alder reaction and double Diels–Alder reaction, where a
secondary Diels–Alder reaction takes place at a different position from that of the conventional
Wagner-Jauregg reaction, of a styrene derivative might be possible with an appropriately
designed diene moiety.
In this article we will describe a triple Diels–Alder reaction of 1 (Scheme 1, eq. 3) and a novel
double Diels–Alder type reaction of 2 (Scheme 1 eq. 4), yielding six-membered cyclic
compounds containing multiple rings. Results from our experiments are supported by
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theoretical calculations.
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Recently, we have developed a one-pot enyne metathesis / Diels–Alder reaction / oxidation
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methodology to yield six-membered silacycles that contain multiple rings (Scheme 2). We
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considered that the key intermediates 1 and 3 in the above one-pot reactions and the isomer of
1, 2 might offer further examples of multiple Diels–Alder reaction.
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Scheme 2. One-pot enyne metathesis / Diels–Alder reaction / oxidation.
O
A
O
O
Grubbs II
A
(0.5 mol%)
Si
R3
toluene
rt, 1 h
O
Si
R1 R2
1
R1 R2
rt, 1 h
A = CH=CH, O, NPh
R3
Si
R3
R1 R2
3
R1 = Me, Ph. R2 = Me, Ph. R3 = H, OMe, F
O
DDQ
A
100 °C, 3 h
up to 78%
(3 steps)
O
2
Si
Si
R3
R3
R1 R2
R1 R2
Scheme 3. Diels–Alder reactions between 3 and N-phenylmaleimide.
3DA calculation
Ph
30
20
10
0
O
23.6
N
O
O
N
Ph
11.2
Ph
O
O
Si
Me Me
N
O
O
0
N
Ph
O
-5.6
O
O
Si
N
Ph
Me Me
N
O
Ph
-10
-20
O
-17.7
Si
Me Me
3
TS1
intermediate
1
TS2
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Results and Discussion
First, we calculated a Diels–Alder reaction between 3 and N-phenylmaleimide by density
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functional theory (DFT) using the B3LYP functional and the 6-31G* basis set. We found
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that two more domino Diels–Alder reactions on 3 are theoretically possible (Scheme 3). Then
we used 1a, generated by enyne metathesis of 4a, and N-phenylmaleimide (10 equiv.) under
refluxing xylene conditions (Scheme 4). As a result, we successfully obtained the expected
product 5a, via the theoretically predicted subsequent two extra Diels–Alder reactions on 3,
in 75% yield as a single diastereoisomer (Table 1, entry 2).
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We continued our experiments to determine the substituent effects on the benzene ring (Table
1, runs 3–8). The enyne metathesis of 4 proceeded quantitatively, as determined by thin layer
chromatography (TLC), regardless of the substituent attached to aromatic ring. However, the
triple Diels–Alder reaction was affected by substituents on the aromatic ring. Therefore, the
electronic effects of the substituents on the aromatic ring controlled the substrate reactivity
toward the triple Diels–Alder reaction. Higher yields of triple Diels–Alder reaction products
5b, 5c, and 5d were obtained with the use of substrates with an electron-releasing group on the
aromatic ring.10 The structure of 5c was determined by single crystal X-ray diffraction (Figure
1).
Table 1. Triple Diels–Alder reaction of 1.
Ph
O
Ph
N
O
N Ph
N
O
O
O
Grubbs II
(1 mol%)
4
5
Si
R
p-xylene
rt, 2 h
6
O
R
Si
Me Me
1
reflux, 3 h
Me Me
R
O
Si
4
Me Me 5
N
O
Ph
Entry Substrate
Product
R =
isolated yield (%, 4 steps)
a
1
2
3
4
5
6
7
4a
4a
4b
4c
4d
4e
4f
H
5a
5a
5b
5c
5d
5e
5f
0
H
75
77
95
64
48
40
60
4-OMe
5-OMe
6-OMe
4-F
5-F
8
4g
6-F
5g
a
The reaction was performed at room temperature.
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Figure 1. X-ray structure of 5c.
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Table 2. One-pot enyne metathesis / triple Diels–Alder reaction of 4 to 5.
Ph
O
Ph
N
N
O
O
O
O
Grubbs II
(1 mol%)
4
5
N Ph
X
p-xylene
rt, 2 h
6
O
X
reflux, 3 h
O
X
4
1
5
N
O
Ph
Entry Substrate
Product
X =
isolated yield (%, 4 steps)
1
2
3
4a
4h
4i
SiMe2
CMe2
NTs
5a
5h
5i
75
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The effects of a silane element on this reaction were then investigated (Table 2). Not only
carbon analogue 4h but also nitrogen analogue 4i were converted to the corresponding products
5 in moderate to good yields through the same one-pot enyne metathesis / triple Diels–Alder
reaction. Although we tried the same reaction between 1a and other dienophiles, such as maleic
anhydride and 1,4-benzoquinene, we could not obtain the corresponding products 5.
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Next, we calculated a Diels–Alder reaction between 2 and N-phenylmaleimide by DFT using
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the B3LYP functional and the 6-31G* basis set. We found that a double Diels–Alder reaction
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was theoretically possible, with a secondary Diels–Alder reaction taking place with a styrene
derivative at a different position from that of the conventional Wagner-Jauregg reaction
(Scheme 4). Hence, we placed 2a, generated by enyne metathesis / isomerization of 4a, and
N-phenylmaleimide in refluxing toluene (Scheme 4). As a result, we successfully obtained
the corresponding product 6a, via the theoretically expected double Diels–Alder reaction, in
82% yield as a single diastereoisomer (Table 3, Entry 2). The structure of 6a was determined
by single crystal X-ray diffraction (Figure 2).
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Scheme 4. Diels–Alder reactions between 2 and N-phenylmaleimide.
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(a) New type Diels–Alder reaction
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2DA calculation
Ph
O
16.7
20
10
N
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O
0
2.3
Ph
O
Si
Me Me
0
N
O
-12.1
O
NPh
-10
-20
-30
-40
Si
O
Me Me
Si
Me Me
-32.6
2
TS3
intermediate
2
TS4
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(b) Conventional double Diels–Alder reaction (Wagner-Jauregg reaction).
2DA minor caluculation
Ph
O
16.7
20
10
N
O
5.2
Ph
O
0
N
O
Si
Me Me
-12.1
0
-10
-20
-30
-40
O
Si
Me Me
Si
N
Me Me
O
Ph
-31.7
2
TS3
intermediate
2
TS5
6'
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Table 3. Double Diels–Alder reaction of 2.
5
6
7
8
Ph
O
N
Ph
N
1) Grubbs II (1 mol%)
toluene
O
O
O
O
4
NPh
9
rt, 2 h
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5
O
Si
R
6
R
Si
Me Me
2
2) RuHCl(CO)(PPh3)3
(5 mol%)
reflux, 3 h
Me Me
R
Si
Me Me
4
6
reflux, 3 h
Entry Substrate
Product
R =
isolated yield (%, 4 steps)
a
1
2
3
4
5
6
7
8
4a
4a
4b
4c
4d
4e
4f
H
6a
6a
6b
6c
6d
6e
6f
0
H
82
4-OMe
5-OMe
6-OMe
4-F
95
quant.
85
59
5-F
51
4g
6-F
6g
55
a
The reaction was performed at room temperature.
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Figure 2. X-ray structure of 6a.
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On the basis of these results, we next examined the effects of substituents on the benzene ring
(Table 3, Entries 3–8). Methoxy derivatives 4b–d were converted to the corresponding cyclized
products 4b–4d in excellent to quantitative yields; the variation of the yields was likely the
result of electron donating effects. Derivatives 4e–4g, with electron-withdrawing groups on the
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benzene ring, did not participate in the reaction well.
We continued our experiments to determine the effects of substituents on the allyl silane
moieties (Table 4). We found that both diphenylsilyl analogue 4j and its carbon analogue 4h
were converted to the corresponding products 6 in moderate yields through one-pot enyne
metathesis / isomerization / double Diels–Alder reaction (Entries 2 and 3). We tried the same
reaction between 2a, prepared from 4a, and other dienophiles and found that we could also use
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maleic anhydride as a dienophile. Thus, we obtained 6k from 4a in 71% yield (Figure 3).
Table 4. One-pot enyne metathesis / isomerization / double Diels–Alder reaction of 4 to 6.
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Ph
O
N
Ph
N
1) Grubbs II (1 mol%)
toluene
O
O
O
O
NPh
rt, 2 h
O
X
X
2) RuHCl(CO)(PPh3)3
(5 mol%)
reflux, 3 h
X
4
2
6
reflux, 3 h
Entry Substrate
Product
X =
isolated yield (%, 4 steps)
1
2
3
4a
4h
4j
SiMe2
CMe2
SiPh2
6a
6h
6j
82
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Figure 3. Structure of 6k.
O
O
O
O
O
O
Si
Me2
6k
In summary, we have developed novel multiple Diels–Alder reactions based on theoretical
considerations. Namely, a triple Diels–Alder reaction and a new type of double Diels–Alder
reaction, for which the secondary Diels–Alder reaction takes place at a different position from
that of a conventional Wagner-Jauregg reaction.
Experimental Section
General Information
Chemicals and solvents were either purchased from commercial suppliers or purified by
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standard techniques. All reactions were performed under N2 atmosphere unless otherwise noted.
For thin-layer chromatography (TLC), silica gel plates Merck 60 F254. 1H NMR were recorded
13
at 300 MHz, 400 MHz and 500 MHz. C NMR spectra were recorded at 101 MHz and 126
MHz. Chemical shifts are given in ppm relative to tetramethylsilane (TMS) and the coupling
constants J are given in Hz. The spectra were recorded in CDCl3 as solvent at room temperature
unless otherwise noted. TMS served as internal standard (δ = 0 ppm) for 1H NMR, CDCl3 was
used as internal standard (δ = 77.0 ppm) for 13C NMR. Column chromatography was performed
with silica gel 60N (spherical, neutral, 63-210 µm, Kanto Chemical Co., Inc.), flash silica gel
60 (spherical, acid, 40-50 µm, Kanto Chemical Co., Inc.) and flash silica gel 60N (spherical,
neutral, 40-50 µm, Kanto Chemical Co., Inc.) unless otherwise noted. Melting points were
determined at heated plate and are uncorrected. HRMS (m/z) were measured using MALDI
(Matrix Assisted Laser Desorption/Ionization) techniques unless otherwise noted. 4a-4c, 4e, 4f
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and 4h - 4j are known compounds. 4d and 4g are known compounds
Triple Diels-Alder reaction
General procedure A
To a solution of 4 in p-xylene (0.2 M) was added Grubbs II (1 mol%) and the mixture was
stirred at room temperature for 2 h. Then N-phenyl maleimide(10 eq.) was added to the reaction
mixture and the mixture was refluxed for 3 h. The solvent was evaporated and the residue was
subjected to column chromatography(n-hexane/AcOEt = 1/1) on neutral flash silica gel to give
5.
5a: Compound 5a (75%, 0.0752 mmol, 54.1 mg) was prepared from 4a
1
(0.100 mmol, 20.0 mg) by a general procedure A. H-NMR (DMSO-D6,
500 MHz) δ: 7.52-7.50 (2H, m), 7.46-7.44 (5H, m), 7.40-7.35 (2H, m),
7.22 (2H, d, J = 7.4 Hz), 7.12 (4H, dd, J = 7.4, 7.4 Hz), 6.33-6.31 (1H,
m), 6.20 (1H, d, J = 8.0 Hz), 3.56-3.54 (1H, m), 3.43 (1H, t, J = 7.7 Hz), 3.34-3.33 (1H, m),
3.27-3.25 (1H, m), 3.20 (1H, d, J = 8.0 Hz), 3.15 (1H, d, J = 7.4 Hz), 2.98 (1H, td, J = 13.2,
5.5 Hz), 2.86-2.84 (1H, m), 2.71 (1H, d, J = 6.9 Hz), 2.22 (1H, d, J = 14.0 Hz), 2.11 (1H, d, J
= 13.2 Hz), 2.00 (1H, t, J = 13.2 Hz), 0.88 (1H, dd, J = 14.0, 5.5 Hz), 0.33 (3H, s), -0.18 (3H,
s). 13C-NMR (DMSO-D6, 125 MHz) δ: 179.2, 178.4, 177.3, 177.2, 176.7, 175.7, 136.1, 135.2,
134.6, 132.5, 132.4, 132.2, 130.3, 129.0, 128.8, 128.8, 128.4, 128.3, 128.2, 127.4, 127.0, 126.8,
48.7, 47.7, 45.5, 45.4, 44.6, 43.6, 40.2, 35.8, 34.6, 34.2, 30.0, 24.8, 10.1, -2.2, -3.9. HRMS
+
(MALDI-TOF) calcd for C43H38N3O6Si: 720.2524 ([M+H] ), found 720.2532 ([M+H] ). m.p.
+
294.0-295.0 °C (recrystallized from CHCl3, a colorless column)
5b: Compound 5b (77%, 0.0767 mmol, 57.5 mg) was prepared from 4b (0.100 mmol, 23.0
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mg) by a general procedure A. H-NMR (CDCl3, 500 MHz) δ: 7.52-7.50
5
6
7
8
(2H, m), 7.44-7.42 (5H, m), 7.36-7.35 (2H, m), 7.15 (6H, dd, J = 15.5, 8.0
Hz), 6.71 (1H, d, J = 8.6 Hz), 6.09 (1H, d, J = 9.2 Hz), 3.79 (3H, s), 3.54
(1H, t, J = 8.3 Hz), 3.46 (1H, t, J = 7.2 Hz), 3.37 (1H, d, J = 8.0 Hz), 3.27
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(1H, td, J = 14.4, 6.9 Hz), 3.22 (2H, td, J = 9.2, 4.1 Hz), 3.11 (1H, d, J = 8.0 Hz), 3.03-2.99
(1H, m), 2.62 (1H, dd, J = 7.5, 2.9 Hz), 2.39 (1H, dd, J = 14.3, 2.9 Hz), 2.25-2.20 (1H, m),
2.18-2.13 (1H, m), 0.96 (1H, dd, J = 14.9, 6.3 Hz), 0.47 (3H, s), -0.13 (3H, s). 13C-NMR (CDCl3,
125 MHz) δ: 178.8, 178.1, 176.3, 175.4, 174.6, 173.6, 136.1, 135.4, 135.1, 131.7, 131.6, 131.5,
129.5, 129.2, 129.1, 129.0, 129.0, 128.7, 128.5, 126.5, 126.1, 125.9, 80.5, 52.7, 51.2, 50.3, 49.0,
45.1, 44.9, 40.7, 40.3, 35.8, 34.6, 30.5, 24.9, 10.6, -1.6, -3.9. HRMS (MALDI-TOF) calcd for
C44H40N3O7Si: 750.2630 ([M+H]+), found 750.2629 ([M+H]+). m.p. 255.0-256.0 °C
(recrystallized from CHCl3, a colorless plate)
5c: Compound 5c (95%, 0.0945 mmol, 70.9 mg) was prepared from 4c
1
(0.100 mmol, 23.0 mg) by a general procedure A. H-NMR (CDCl3, 300
MHz) δ: 7.47-7.38 (9H, m), 7.18-7.08 (6H, m), 4.74 (1H, d, J = 2.3 Hz),
3.69 (1H, d, J = 2.3 Hz), 3.49-3.42 (1H, m), 3.45 (3H, s), 3.38 (1H, t, J =
8.3 Hz), 3.33 (1H, d, J = 7.5 Hz), 3.25-3.19 (3H, m), 3.08-2.98 (1H, m), 3.00 (1H, dd, J = 7.5,
2.6 Hz), 2.46-2.34 (2H, m), 2.26-2.14 (2H, m), 0.96 (1H, dd, J = 14.6, 6.0 Hz), 0.47 (3H, s), -
0.07 (3H, s). 13C-NMR (CDCl3, 100 MHz) δ: 179.2, 178.5, 176.7, 175.8, 175.5, 174.2, 160.5,
137.1, 135.2, 132.2, 132.1, 132.0, 129.8, 129.6, 129.3, 129.2, 129.0, 128.9, 126.7, 126.6, 126.5,
93.6, 54.9, 50.7, 49.0, 46.2, 45.6, 45.3, 43.6, 40.9, 40.8, 35.5, 34.9, 30.0, 25.5, 11.0, -1.6, -3.1.
HRMS(MALDI-TOF) calcd for C44H40N3O7Si: 750.2630 ([M+H]+), found 750.2639 ([M+H]+).
m.p. 228.0-229.0 °C (recrystallized from CHCl3, a colorless column)
5d:Compound 5d (64%, 0.0652 mmol, 48.1 mg) was prepared from 4d
1
(0.100 mmol, 23.0 mg) by a general procedure A. H-NMR (DMSO-D6,
400 MHz) δ: 7.52-7.43 (7H, m), 7.43-7.36 (2H, m), 7.21 (2H, d, J = 7.8
Hz), 7.09 (2H, d, J = 7.8 Hz), 6.99 (2H, d, J = 7.8 Hz), 4.84 (1H, d, J = 7.3
Hz), 3.49-3.42 (2H, m), 3.39 (3H, s), 3.38-3.37 (1H, m), 3.33-3.31 (1H, m), 3.25 (1H, dd, J =
9.2, 5.0 Hz), 3.17 (1H, d, J = 7.3 Hz), 3.08 (1H, dd, J = 7.3, 2.4 Hz), 2.95 (1H, td, J = 13.7, 6.4
Hz), 2.92-2.84 (1H, m), 2.60-2.56 (1H, m), 2.21 (1H, d, J = 13.7 Hz), 2.10-2.07 (1H, m), 1.95
(1H, dd, J = 14.0, 12.3 Hz), 0.78 (1H, dd, J = 14.0, 5.5 Hz), 0.38 (3H, s), -0.04 (3H, s). 13C-
NMR (DMSO-D6, 100 MHz) δ: 179.2, 178.5, 177.4, 176.8, 176.7, 175.2, 157.8, 135.9, 135.7,
132.5, 132.4, 129.0, 128.9, 128.9, 128.5, 128.5, 128.3, 127.4, 127.2, 127.0, 95.7, 54.9, 49.5,
48.9, 45.6, 45.2, 44.6, 43.5, 36.1, 35.2, 34.7, 34.5, 24.9, 11.1, -1.0, -2.3. HRMS (MALDI-TOF)
+
calcd for C44H39N3O7Si: 749.2552 (M ), found 749.2559 (M ). m.p. >300 °C (recrystallized from
+
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CHCl3, a colorless column)
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5e: Compound 5e (48%, 0.0479 mmol, 35.3 mg) was prepared from 4e
1
(0.100 mmol, 21.8 mg) by a general procedure A. H-NMR (DMSO-D6,
8
9
500 MHz) δ: 7.52-7.36 (9H, m), 7.28-7.27 (2H, m), 7.13-7.10 (4H, m),
6.46 (1H, dd, J = 11.7, 8.9 Hz), 6.18 (1H, dd, J = 8.9, 5.4 Hz), 3.51 (1H, t,
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J = 8.3 Hz), 3.45-3.42 (2H, m), 3.39-3.37 (1H, m), 3.29-3.27 (1H, m), 3.21 (1H, d, J = 8.0 Hz),
3.03-2.97 (2H, m), 2.88-2.82 (1H, m), 2.35-2.29 (1H, m), 2.11 (1H, dd, J = 11.7, 4.0 Hz), 1.98
(1H, dd, J = 14.6, 11.7 Hz), 0.90 (1H, dd, J = 14.6, 6.0 Hz), 0.32 (3H, s), -0.20 (3H, s). 13C-
NMR (DMSO-D6, 125 MHz) δ: 179.1, 178.4, 177.1, 176.1, 174.6, 173.0, 135.9, 135.8, 134.8
(J = 25 Hz), 133.7 (J = 7 Hz), 132.5, 132.4, 132.2, 128.9, 128.9, 128.8, 128.6 (J = 7 Hz), 128.5,
128.2, 127.6, 127.1, 126.9, 96.0 (J =199 Hz), 51.0 (J = 17 Hz), 49.5 (J = 20 Hz), 48.9, 48.9,
45.0, 44.4, 40.8, 34.7, 34.2, 30.1, 24.5, 9.9, -2.2, -4.0. 19F-NMR (CDCl3, 376 MHz) δ: -185.10.
HRMS(MALDI-TOF) calcd for C43H36N3O6FNaSi:760.2250 ([M+Na]+), found 760.2245
([M+Na]+). m.p. 226.0-227.0 °C (recrystallized from CHCl3, a colorless needle)
5f: Compound 5f (40%, 0.0400 mmol, 29.5 mg) was prepared from 4f
1
(0.100 mmol, 21.8 mg) by a general procedure A. H-NMR (CDCl3, 400
MHz) δ: 7.52-7.33 (9H, m), 7.17-7.13 (6H, m), 5.42 (1H, dd, J = 5.3, 2.5
Hz), 3.87-3.84 (1H, m), 3.49-3.45 (1H, m), 3.39 (1H, t, J = 8.5 Hz), 3.34
(1H, dd, J = 7.6, 2.1 Hz), 3.27-3.21 (3H, m), 3.13-3.10 (1H, m), 3.04-2.97 (1H, m), 2.51-2.47
(1H, m), 2.39 (1H, ddd, J = 14.2, 4.1, 1.4 Hz), 2.25-2.22 (1H, m), 2.22-2.15 (1H, m), 0.97 (1H,
dd, J = 14.7, 6.0 Hz), 0.44 (3H, s), -0.20 (3H, s). 13C-NMR (CDCl3, 100 MHz) δ: 179.0, 178.4,
176.5, 175.3, 174.9, 174.5, 162.6 (J = 288 Hz), 136.9, 135.4, 131.9 (J = 2 Hz), 131.7, 129.8,
129.6, 129.4, 129.3, 129.2, 128.8, 126.9, 126.4, 126.0, 104.1, 104.0, 49.6, 49.2, 46.5, 45.3 (J =
27 Hz), 43.4, 40.6, 39.1 (J = 22 Hz), 35.6, 35.0, 30.9, 30.839, 25.439, 10.9, -1.8, -3.6. 19F-NMR
(CDCl3, 376 MHz) δ: 98.70 (J = 12 Hz). HRMS(MALDI-TOF) calcd for
C43H36N3O6FNaSi:760.2250 ([M+Na]+), found 760.2246 ([M+Na]+). m.p. 228.0-229.0 °C
(recrystallized from CHCl3, a colorless column)
5g: Compound 5g (60%, 0.0603 mmol, 44.5mg) was prepared from 4g
1
(0.100 mmol, 21.8 mg) by a general procedure A. H-NMR (DMSO-D6,
300 MHz) δ: 7.48-7.43 (9H, m), 7.23-7.21 (2H, m), 7.11-7.07 (4H, m),
5.56 (1H, t, J = 6.7 Hz), 3.62-3.57 (1H, m), 3.47-3.38 (3H, m), 3.30-3.24
(2H, m), 3.20-3.16 (1H, m), 2.98 (1H, td, J = 14.1, 6.5 Hz), 2.93-2.84 (1H, m), 2.69-2.63 (1H,
m), 2.28-2.08 (2H, m), 1.99 (1H, t, J = 14.1 Hz), 0.88 (1H, dd, J = 14.1, 5.1 Hz), 0.39 (3H, s),
13
-0.10 (3H, s). C-NMR (DMSO-D6, 100 MHz) δ: 179.2, 178.5, 177.4, 177.0, 176.3, 175.0,
160.8 (J = 271 Hz), 136.4, 134.8 (J = 3 Hz), 132.4, 132.3, 132.2, 129.0, 129.0, 128.9, 128.5,
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128.4, 127.5, 127.0, 126.7, 105.7, 105.6, 50.0, 48.1, 45.6, 44.8, 44.4, 43.4, 35.5 (J = 5 Hz),
35.3, 34.9, 34.9, 34.3, 24.7, 10.2, -1.4, -3.3 (J = 7 Hz)
19F-NMR (CDCl3, 376 MHz) δ: -101.85. HRMS(MALDI-TOF) calcd for
C43H37N3O6FSi:738.2430 (M+), found 738.2430 (M+). m.p. 242.0-243.0 °C (recrystallized
from CHCl3, a colorless needle)
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5h: Compound 5h (59%, 0.0593 mmol, 41.7 mg) was prepared from 4h
1
(0.100 mmol, 18.4 mg) by a general procedure A. H-NMR (DMSO-D6,
400 MHz) δ: 7.52-7.35 (9H, m), 7.22-7.19 (2H, m), 7.11-7.06 (4H, m),
6.35 (1H, d, J = 8.2 Hz), 6.14 (1H, dd, J = 8.2, 6.2 Hz), 3.53-3.46 (2H, m),
3.44-3.39 (2H, m), 3.31-3.27 (2H, m), 3.15 (1H, d, J = 7.8 Hz), 2.95 (1H, td, J = 13.3, 5.5 Hz),
13
2.75-2.65 (3H, m), 2.29-2.14 (2H, m), 1.43 (1H, d, J = 7.8 Hz), 1.29 (3H, s), 0.81 (3H, s). C-
NMR (CDCl3, 100 MHz) δ: 178.8, 177.6, 176.6, 175.8, 175.6, 174.4, 135.8, 132.8, 132.7, 132.7,
131.9, 131.6, 131.5, 129.4, 129.2, 129.1, 128.9, 128.7, 128.7, 126.6, 126.2, 126.1, 49.7, 49.6,
48.5, 44.8, 44.6, 43.6, 41.1, 40.3, 35.6, 35.1, 34.7, 33.7, 31.9, 28.6, 26.7, 24.3. HRMS(MALDI-
TOF) calcd for C44H37N3O6Na:726.2575 ([M+Na]+), found 726.2573 ([M+Na]+). m.p. 251.0-
252.0 °C (recrystallized from CHCl3, a colorless needle)
5i: Compound 5i (49%, 0.0485 mmol, 40.3 mg) was prepared from 4i
1
(0.100 mmol, 31.1 mg) by a general procedure A. H-NMR (DMSO-D6,
400 MHz) δ: 7.54-7.37 (11H, m), 7.28 (2H, d, J = 7.3 Hz), 7.21 (2H, d, J
= 7.3 Hz), 7.01 (2H, d, J = 8.2 Hz), 6.92 (2H, dd, J = 6.4, 3.0 Hz), 6.76
(1H, d, J = 8.8 Hz), 6.04 (1H, dd, J = 8.8, 6.4 Hz), 4.35 (1H, dd, J = 15.0, 5.5 Hz), 4.22 (1H,
dd, J = 11.0, 15.0 Hz), 3.61-3.59 (1H, m), 3.56-3.45 (5H, m), 3.27 (1H, d, J = 8.2 Hz), 2.93-
13
2.91 (2H, m), 2.90-2.80 (1H, m), 2.41-2.33 (1H, m), 2.20-2.15 (1H, m), 2.15 (3H, s). C-NMR
(DMSO-D6, 100 MHz) δ: 178.9, 177.5, 177.0, 176.7, 176.1, 172.8, 142.4, 140.8, 134.0, 132.3,
132.3, 132.0, 130.2, 129.8, 129.0, 128.9, 128.8, 128.6, 128.3, 128.3, 127.4, 126.7, 126.7, 125.2,
63.4, 46.8, 45.9, 44.6, 43.4, 42.3, 40.2, 39.0, 33.5, 31.2, 31.0, 23.9, 20.9. HRMS(MALDI-TOF)
+
calcd for C48H38N4O8NaS: 853.2303 ([M+Na] ), found 853.2298 ([M+Na] ). m.p. 222.0-223.0 °C
+
(recrystallized from CHCl3, a colorless column)
Double Diels-Alder reaction
general procedure B
To a solution of 4 in toluene (0.2 M) was added Grubbs II (1 mol%) and the mixture was
stirred at room temperature for 2 h. Then RuHCl(CO)(PPh3)3 (5 mol%) was added to the
mixture and the mixture was refluxed for 3 h. N-phenyl maleimide(5.0 eq.) was added to the
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reaction mixture and the mixture was refluxed for 3 h. The solvent was evaporated and the
residue was subjected to column chromatography(n-hexane/AcOEt = 2/1) on neutral flash
silica gel to give 6.
6a: Compound 6a (82%, 0.0820 mmol, 44.8 mg) was prepared from 4a (0.100
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mmol, 20.0 mg) by a general procedure B. H-NMR (CDCl3, 300 MHz) δ: 7.48-
7.28 (6H, m), 7.19-7.16 (2H, m), 7.11-7.07 (2H, m), 6.50-6.43 (2H, m), 6.40-
6.34 (1H, m), 6.12 (1H, dd, J = 8.3, 2.4 Hz), 4.27 (1H, t, J = 6.4 Hz), 3.31-3.28
(1H, m), 3.23-3.19 (2H, m), 2.96 (1H, d, J = 8.3 Hz), 2.76-2.70 (1H, m), 2.66 (1H, d, J = 8.3
13
Hz), 1.54 (3H, d, J = 2.8 Hz), 0.25 (3H, s), -0.26 (3H, s). C-NMR (CDCl3, 100 MHz) δ: 179.0,
176.3, 175.7, 174.9, 138.2, 137.7, 136.4, 132.0, 131.8, 129.2, 128.8, 128.7, 128.0, 128.4, 127.4,
126.5, 125.5, 123.7, 48.7, 45.2, 44.3, 41.6, 40.4, 32.5, 32.5, 28.4, 15.2, -2.7, -4.2. HRMS
(MALDI-TOF) calcd for C33H31N2O4Si: 547.2048 ([M+H]+), found 547.2043 ([M+H]+). m.p.
281.5-282.0 °C (recrystallized from CHCl3, a colorless column).
6b: Compound 6b (95%, 0.0953 mmol, 55.0 mg) was prepared from 4b (0.100
1
mmol, 23.0 mg) by a general procedure B. H-NMR (CDCl3, 500 MHz) δ: 7.45-
7.36 (6H, m), 7.32-7.29 (1H, m), 7.19-7.16 (2H, m), 7.12-7.09 (2H, m), 6.44
(1H, d, J = 6.3 Hz), 6.10 (1H, dd, J = 8.0, 2.3 Hz), 5.53 (1H, d, J = 6.3 Hz),
4.25 (1H, d, J = 8.0 Hz), 3.80 (3H, s), 3.39 (1H, dd, J = 9.7, 8.0 Hz), 3.34 (1H, d, J = 8.0 Hz),
3.25 (1H, dd, J = 9.7, 4.6 Hz), 2.93 (1H, d, J = 8.0 Hz), 2.72-2.67 (1H, m), 2.63 (1H, d, J = 8.0
Hz), 1.53 (3H, d, J = 6.9 Hz), 0.24 (3H, s), -0.26 (3H, s). 13C-NMR (CDCl3, 125 MHz) δ: 179.2,
176.5, 175.9, 174.6, 159.8, 138.3, 136.9, 132.0, 131.8, 129.2, 128.7, 128.0, 126.5, 126.5, 125.6,
123.6, 97.2, 55.5, 48.6, 47.5, 44.2, 40.8, 40.6, 37.7, 32.5, 28.6, 15.1, -2.4, -4.2. HRMS
(MALDI-TOF) calcd for C33H32N2O5NaSi: 599.1973 ([M+Na]+), found 599.1981 ([M+Na]+).
m.p. 237.0-238.0 °C (recrystallized from CHCl3, a colorless needle)
6c: Compound 6c (quant, 0.100 mmol, 57.6 mg) was prepared from 4c (0.100
1
mmol, 23.0 mg) by a general procedure B. H-NMR (CDCl3, 500 Hz) δ: 7.45
(2H, dd, J = 7.7, 7.7 Hz), 7.40-7.37 (3H, m), 7.30 (1H, dd, J = 7.4, 7.4 Hz),
7.17 (2H, d, J = 7.4 Hz), 7.10 (2H, d, J = 7.4 Hz), 6.29 (1H, d, J = 2.3 Hz),
6.11 (1H, dd, J = 8.6, 2.3 Hz), 5.15 (1H, dd, J = 6.9, 2.3 Hz), 4.35 (1H, t, J = 7.2 Hz), 3.75 (3H,
s), 3.39 (1H, d, J = 8.6 Hz), 3.24-3.16 (2H, m), 2.97 (1H, d, J = 8.6 Hz), 2.77-2.73 (1H, m),
2.66 (1H, d, J = 8.6 Hz), 1.54 (3H, d, J = 6.9 Hz), 0.27 (3H, s), -0.25 (3H, s). 13C-NMR (CDCl3,
125 MHz) δ: 178.9, 176.2, 175.8, 175.3, 154.6, 140.5, 138.7, 135.8, 132.1, 131.8, 129.2, 128.8,
128.7, 127.9, 126.5, 125.5, 123.6, 92.9, 54.7, 48.7, 46.0, 44.3, 42.7, 40.3, 32.6, 32.5, 28.5, 15.1,
-2.9, -4.3. HRMS (MALDI-TOF) calcd for C34H33N2O5Si: 577.2153 ([M+H]+), found
577.2156 ([M+H]+). m.p. 226.0-227.0 °C (recrystallized from CHCl3, a colorless needle)
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6d: Compound 6d (85%, 0.0850 mmol, 49.0 mg) was prepared from 4d (0.100
5
6
1
mmol, 23.0 mg) by a general procedure B. H-NMR (CDCl3, 300 MHz) δ: 7.47-
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8
9
7.32 (6H, m), 7.17-7.15 (2H, m), 7.11-7.07 (2H, m), 6.62 (1H, d, J = 10.0 Hz),
6.54 (1H, dd, J = 10.0, 6.2 Hz), 6.10 (1H, dd, J = 8.3, 2.4 Hz), 4.22 (1H, t, J =
6.7 Hz), 3.71 (3H, s), 3.27-3.20 (2H, m), 3.13 (1H, dd, J = 9.8, 7.0 Hz), 2.99 (1H, dd, J = 8.3,
0.7 Hz), 2.74-2.68 (1H, m), 2.57 (1H, d, J = 8.3 Hz), 1.52 (3H, d, J = 6.9 Hz), 0.32 (3H, s), -
0.21 (3H, s). 13C-NMR (CDCl3, 100 MHz) δ: 179.4, 176.4, 175.8, 161.8, 138.1, 132.1, 132.0,
130.6, 129.3, 128.8, 128.8, 128.3, 126.5, 124.4, 123.1, 107.9, 55.7, 48.8, 46.2 44.4, 41.1, 40.8,
33.3, 32.7, 29.1, 15.2, -2.1, -3.9. HRMS (MALDI-TOF) calcd for C34H32N2O5NaSi: 599.1973
([M+Na]+), found 599.1970 ([M+Na]+). m.p. 226.0-227.0 °C (recrystallized from CHCl3, a
colorless column)
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1
mmol, 21.8 mg) by a general procedure B. H-NMR (CDCl3, 400 MHz) δ: 7.47-
7.37 (5H, m), 7.33-7.30 (1H, m), 7.19-7.15 (2H, m), 7.11-7.07 (2H, m), 6.39 (1H,
dd, J = 6.9, 6.0 Hz), 6.14 (1H, dd, J = 8.2, 1.8 Hz), 6.04 (1H, dd, J = 11.0, 6.4
Hz), 4.44 (1H, dd, J = 12.6, 7.7 Hz), 3.40 (1H, dd, J = 10.1, 7.7 Hz), 3.33 (1H, d, J = 8.2 Hz),
3.27 (1H, dd, J = 9.8, 4.8 Hz), 2.96 (1H, d, J = 8.2 Hz), 2.69-2.65 (1H, m), 2.67 (1H, d, J = 8.2
Hz), 1.54 (3H, d, J = 6.9 Hz), 0.25 (3H, s), -0.25 (3H, s). 13C-NMR (CDCl3, 100 MHz) δ: 178.7,
176.1, 175.5, 173.9, 162.3 (J = 255 Hz), 137.1 (J = 3 Hz), 134.8 (J = 8 Hz), 132.7 (J = 5 Hz),
131.7 (J = 18 Hz), 129.2, 128.9, 128.7, 128.1, 126.4, 125.5, 124.3, 105.1, 105.0, 49.0, 48.8 (J
= 6 Hz), 43.7, 40.4, 39.8 (J = 4 Hz), 35.3 (J = 23.8 Hz), 32.6, 28.5, 15.1, -2.7, -4.3. 19F-NMR
(CDCl3, 470 MHz) δ: -107.48. HRMS (MALDI-TOF) calcd for C33H29N2O4FNaSi: 587.1773
([M+Na]+), found 587.1768 ([M+Na]+). m.p. 299.0-300 °C (recrystallized from CHCl3, a
colorless needle)
6f: Compound 6f (51%, 0.0512 mmol, 28.9 mg) was prepared from 4f (0.100
1
mmol, 21.8 mg) by a general procedure B. H-NMR (CDCl3, 300 MHz) δ: 7.48-
7.38 (5H, m), 7.34-7.27 (1H, m), 7.17 (2H, d, J = 7.6 Hz), 7.09 (2H, d, J = 7.2
Hz), 6.36 (1H, dd, J = 6.5, 2.1 Hz), 6.15 (1H, dd, J = 8.3, 2.1 Hz), 5.74 (1H, ddd,
J = 11.0, 6.5, 2.4 Hz), 4.43-4.37 (1H, m), 3.38 (1H, d, J = 8.3 Hz), 3.27-3.20 (2H, m), 2.99 (1H,
d, J = 8.3 Hz), 2.75-2.68 (1H, m), 2.70 (1H, d, J = 8.3 Hz), 1.55 (3H, d, J = 6.9 Hz), 0.29 (3H,
13
s), -0.23 (3H, s). C-NMR (CDCl3, 100 MHz) δ: 178.5, 175.8, 175.5, 174.8, 158.1 (J = 254
Hz), 143.7 (J = 6 Hz), 137.8, 131.9 (J = 32 Hz), 131.7 (J = 20 Hz), 129.3, 128.9, 128.7, 128.1,
126.4, 125.4, 124.1, 102.0, 101.8, 48.6, 45.8, 43.9, 41.8 (J = 4 Hz), 40.2, 32.5, 32.2 (J = 7 Hz),
28.4, 15.1, -3.0, -4.4. HRMS (MALDI-TOF) calcd for C33H29N2O4FNaSi: 587.1773 ([M+Na]+),
found 587.1774 ([M+Na]+). 19F-NMR (CDCl3, 470 MHz) δ: -121.01. Anal. calcd for
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C33H29N2O4FSi: C, 70.19; H, 5.18; N, 4.96, found: C, 69.90; H, 5.25; N, 4.97. m.p. 241.0-
242.0 °C (recrystallized from CHCl3, column)
6g: Compound 6g (55%, 0.0552 mmol, 31.2 mg) was prepared from 4g (0.100
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mmol, 21.8 mg) by a general procedure B. H-NMR (CDCl3, 300 MHz) δ: 7.48-
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7.29 (7H, m), 7.17-7.13 (2H, m), 7.11-7.07 (2H, m), 6.53 (1H, ddd, J = 10.0, 6.5,
6.5 Hz), 6.37 (1H, dd, J = 10.0, 5.5 Hz), 6.12 (1H, dd, J = 8.3, 2.4 Hz), 4.31 (1H,
t, J = 6.7 Hz), 3.30 (1H, d, J = 8.3 Hz), 3.26 (1H, dd, J = 9.9, 4.5 Hz), 3.18 (1H, dd, J = 9.9,
7.1 Hz), 3.03 (1H, d, J = 8.3 Hz), 2.74-2.70 (1H, m), 2.64 (1H, d, J = 8.3 Hz), 1.54 (3H, d, J =
6.9 Hz), 0.39 (3H, d, J = 1.4 Hz), -0.24 (3H, s). 13C-NMR (CDCl3, 100 MHz) δ: 178.6, 175.9,
175.4, 174.9, 165.0 (J = 250 Hz), 137.8, 132.1 (J = 10 Hz), 131.7, 131.7, 129.0 (J = 39 Hz),
128.8, 128.1, 126.4, 125.7, 124.2, 123.9 (J = 39 Hz), 109.3, 109.0, 48.5 (J = 3.8 Hz), 46.0 (J =
12.4 Hz), 44.2, 41.3, 40.3, 33.4, 32.6, 28.4, 15.1, -3.0, -4.5 (J = 3 Hz). 19F-NMR (CDCl3, 376
MHz) δ: -100.45. HRMS (MALDI-TOF) calcd for C33H29N2O4FNaSi: 587.1773 ([M+Na]+),
found 587.1771 ([M+Na]+). Anal. calcd for C33H29N2O4FSi: C, 70.19; H, 5.18; N, 4.96, found:
C, 70.25; H, 5.33; N, 5.05. m.p. 287.0-288.0 °C (recrystallized from CHCl3, a colorless
column)
6h: Compound 6h (62%, 0.0616 mmol, 32.7 mg) was prepared from 4h (0.100
1
mmol, 18.4 mg) by a general procedure B. H-NMR (CDCl3, 500 MHz) δ: 7.45
(2H, dd, J = 7.7, 7.7 Hz), 7.38 (3H, dd, J = 7.7, 7.7 Hz), 7.29 (1H, dd, J = 7.4,
7.4 Hz), 7.18 (2H, d, J = 8.3 Hz), 7.08 (2H, d, J = 8.3 Hz), 6.38 (1H, dd, J = 9.4,
5.7 Hz), 6.20 (1H, dd, J = 6.9, 2.3 Hz), 6.08 (1H, dd, J = 9.4, 6.3 Hz), 5.92 (1H, d, J = 6.3 Hz),
4.20 (1H, t, J = 6.6 Hz), 3.24-3.21 (3H, m), 3.13 (1H, d, J = 7.4 Hz), 3.00 (1H, dd, J = 6.6, 2.6
Hz), 2.75-2.72 (1H, m), 1.54 (3H, d, J = 6.8 Hz), 1.26 (3H, s), 0.76 (3H, s). 13C-NMR (CDCl3,
125 MHz) δ:178.0, 175.8,175.6, 174.4, 145.9, 138.9, 131.8, 131.7, 129.3, 128.8, 128.7, 128.0,
126.9, 126.3, 125.7, 124.9, 122.0, 119.6, 47.2, 45.5, 45.3, 44.2, 41.8, 41.1, 40.2, 33.1, 32.1,
28.7, 27.8, 14.6. HRMS (MALDI-TOF) calcd for C34H30N2O4Na: 553.2098 ([M+Na]+), found
553.2108 ([M+Na]+). m.p. 267.0-268.0 °C (recrystallized from CHCl3, a colorless needle)
6j: Compound 6j (61%, 0.0605 mmol, 40.6 mg) was prepared from 4j (0.100
1
mmol, 32.5 mg) by a general procedure B. H-NMR (CDCl3, 400 MHz) δ: 7.49-
7.42 (6H, m), 7.41-7.36 (3H, m), 7.30-7.25 (2H, m), 7.21-7.16 (4H, m), 7.10 (2H,
d, J = 7.3 Hz), 6.91 (2H, dd, J = 7.3, 7.3 Hz), 6.80-6.76 (3H, m), 6.60 (1H, dd, J
= 9.3, 5.1 Hz), 6.50 (1H, dd, J = 9.3, 6.4 Hz), 6.42 (1H, d, J = 8.2 Hz), 4.38 (1H, t, J = 6.9 Hz),
3.48 (1H, d, J = 8.7 Hz), 3.24-3.13 (4H, m), 2.73-2.68 (1H, m), 1.53 (3H, d, J = 6.9 Hz). 13C-
NMR (CDCl3, 100 MHz) δ: 178.6, 175.9, 174.9, 174.6, 139.1, 138.9, 135.9, 135.4, 133.8, 132.2,
131.9, 131.8, 130.4, 130.3, 129.9, 129.3, 128.8, 128.4, 128.4, 128.2, 127.8, 127.4, 126.9, 126.4,
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125.4, 124.4, 48.9, 45.8, 43.9, 41.4, 40.6, 32.7, 32.6, 27.6, 15.3. HRMS (MALDI-TOF) calcd
for C43H34N2O4NaSi: 693.2180 ([M+Na]+), found 693.2185 ([M+Na]+). m.p. 281.0-282.0 °C
(recrystallized from CHCl3, a colorless needle)
6k: Compound 6k (71%, 0.0711 mmol, 28.2 mg) was prepared from 4a (0.100
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mmol, 20.0 mg) by a general procedure B. H-NMR (CDCl3, 300 MHz) δ: 6.46
(1H, dd, J = 9.6, 5.2 Hz), 6.38 (1H, dd, J = 5.2, 1.6 Hz), 6.24 (1H, ddd, J = 9.6,
6.6, 1.6 Hz), 6.22 (1H, dd, J = 8.3, 2.4 Hz), 3.98 (1H, t, J = 6.6 Hz), 3.39 (1H, d,
J = 10.0 Hz), 3.38-3.25 (3H, m), 3.07 (1H, dd, J = 8.8, 1.1 Hz), 2.71-2.64 (1H, m), 2.66 (1H,
dd, J = 8.1, 1.1 Hz), 1.48 (3H, d, J = 6.9 Hz), 0.24 (3H, s), 0.12 (3H, s). 13C-NMR (CDCl3, 125
MHz) δ: 174.0, 171.2, 171.1, 170.5, 138.1, 137.6, 135.7, 128.4, 125.8, 125.7, 49.9, 45.2, 44.7,
41.0, 40.9, 32.2, 32.2, 28.6, 14.7, -3.1, -4.1. HRMS (MALDI-TOF) calcd for C21H20O6NaSi:
419.0929 ([M+Na]+), found 419.0921 ([M+Na]+). m.p. 281.0-282.0 °C (recrystallized from
CHCl3, a colorless column)
Supporting Information Available
The Supporting Information is available free of charge on the ACS Publications website at
DOI: xxxxxxxxx. Spectral data for all new compounds, computational details and x-ray
crystallographic analysis data .
Acknowledgement
This work was partially supported from JSPS KAKENHI (Grant No. JP A16H010260 and
18H04260) for Precisely Designed Catalysts with Customized Scaffolding, A262880510,
T15K149760, and T15KT00630; the Platform Project for Supporting Drug Discovery and
Life Science Research (Platform for Drug Discovery, Informatics, and Structural Life
Science) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan
(MEXT), JST ACT-C Grant Number JPMJCR12YM, Japan, AMED under Grant Number
17am0101084j0001 and Dynamic Alliance for Open Innovation Bridging Human,
Environment and Materials” from the Ministry of Education, Culture, Sports, Science and
Tachnology of Japan.
References and Notes
1. Diels, O.; Alder, K. Synthesen in der Hydroaromatischen Reihe. VIII. Mitteilung: Dien-
Synthesen des Anthracens. Anthracen-Formel. Ann. Chem. 1928, 460, 96 - 122.
2. Wagner-Jauregg, T. Die Addition von Maleinsäureanhydrid an Asymm. Diphenyl-äthylen.
Chem. Ber. 1930, 63, 3218 - 3224.
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3. a) Bergmann, F.; Szmuszkow, J.; Fawaz, G. The Condensation of 1,1-Diarylethylenes with
Maleic Anhydride. J. Am. Chem. Soc. 1947, 69, 1773 - 1777. b) Rasoul, H. A. A.; Hall, H. K.
Cycloaddition and Polymerization Reactions of Methyl alpha-Cyanoacrylate with Electron-
rich Olefins. J. Org. Chem. 1982, 47, 2080 - 2083. c) Bindu, R. L.; Reghunadhan Nair, C. P.;
Ninan, K. N. Addition-cure-type Phenolic Resin Based on Alder-ene Reaction: Synthesis and
laminate Composite Properties. J. Appl. Polym. Sci. 2001, 80, 737 - 749.
4. Hayashi, Y. One-pot Economy and One-pot Synthesis. Chem. Sci. 2016, 7, 866 – 880.
5. a) Dion, A.; Dubé, P.; Spino, C. A Triple Diene-Transmissive Diels−Alder Strategy to
Build the Quassinoid Framework. Org. Lett. 2005, 7, 5601 – 5604. b) Mannes, P. Z.;
Onyango, E. O.; Gribble, G. W. Triple Benzannulation of Naphthalene via a 1,3,6-
Naphthotriyne Synthetic Equivalent. Synthesis of Dibenz[a,c]anthracene. J. Org. Chem.
2015, 80, 11189 – 11192.
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6. Review of Diene-transmissive Diels-Alder reaction. Hopf, H.; Sherburn, M. S.
Dendralenes Branch Out: Cross-Conjugated Oligoenes Allow the Rapid Generation of
Molecular Complexity. Angew. Chem. Int. Ed. 2012, 51, 2298 - 2338.
7. Yoshioka, S.; Fujii, Y.; Tsujino, H.; Uno, T.; Fujioka, H.; Arisawa, M. One-pot Enyne
metathesis/Diels–Alder/oxidation to Six-membered Silacycles with a Multi-ring Core: Discovery
of Novel Fluorophores. Chem. Commun. 2017, 53, 5970 – 5973.
8. Computational details and citations are given in the Supporting Information. B3LYP/6-
31G* gives activation energies that are about 5 kcal/mol too high and reaction energies about
10 kcal/mol too endergonic. We calculated the stereoisomers which might be more stable due
to the steric repulsion.
9. See also a) Domingo, L. R.; Ríos-Gutiérrez, M.; Silvi, B.; Pérez, P. The Mysticism of
Pericyclic Reactions: A Contemporary Rationalisation of Organic Reactivity Based on
Electron Density Analysis. Eur. J. Org. Chem. 2018, 1107 - 1120. b) Domingo, L. R.; Sáez, J.
A. Understanding the Mechanism of Polar Diels–Alder Reactions. Org. Biomol. Chem. 2009,
7, 3576 – 3583. c) Domingo, L. R.; Ríos-Gutiérrez, M.; Pérez, P. Applications of the
Conceptual Density Functional Theory Indices to Organic Chemistry Reactivity. Molecules
2016, 21, 748.
10. The experimental results can be explained in terms of the P-DA mechanism. Due to the
electrophilic character of N-phenylmaleimida, these P-DA reactions are favored with the
increase of the nucleophilic character of the diene. See reference 8b.
11. CCDC 1831909
12. CCDC 1831910
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13. Takamoto, K.; Yoshioka, S; Fujioka, H.; Arisawa, M. Palladium-Catalyzed Seven-
Membered Silacycle Construction: 1,7-Enyne Hydroxycyclization to Give a Benzosilepine
Skeleton. Org. Lett. 2018, 20, 1773 – 1776.
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Ph
Ph
O
O
N
N
O
O
O
O
N Ph
NPh
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O
R'
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R'
O
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N
X = SiR2,NTs, CMe2, R' = H, OMe, F
O
Ph
via Domino Diels-Alder Reactions of Styrene
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