The Selective Liquid-Phase Oxidation of 3,4,5-Trimethoxytoluene to 3,4,5-Trimethoxybezaldehyde

Article abstract of DOI:10.1246/bcsj.61.1035

The selective liquid-phase oxidation of 3,4,5-trimethoxytoluene to 3,4,5-trimethoxybenzaldehyde, an important chemical intermediate for medicine production, was developed; when 2.0 mmol of the reactant was heated at 110 deg C for 2 h in an autoclave under 3 atm O2 with 10 ml of acetic acid in the presence of 0.75 mmol of Co(OAc)2-Mn(OAc)2 (3:1 mol ratio), a 92percent yield of the aldehyde was obtained.