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comparable in magnitude to other aromatic interactions. Further
studies are underway to explore the scope and driving force of this
interaction.
This work was supported in part from the NIH (GM071589
and GM072691), the STC Program of the National Science
Foundation under Agreement No. CHE-9876674, and an Alfred
P. Sloan Fellowship to MLW.
Notes and references
{ Selective upfield shifting of the protons on the a-face of a carbohydrate
has been observed in an NMR titration with phenol in aqueous solution,
although the magnitude of upfield shifting was very small (6–14 Hz). See
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observed in some host–guest complexes in water (ref. 9a) and CD3CN–
CD3OD (ref. 9c).
§ ClogP is the calculated octanol–water partition constant. Values were
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