THREE-STEP SYNTHESIS OF 4-(2'-HYDROXYETHYL)AZETIDIN-2-ONE AND ITS SUBSTITUTED DERIVATIVES FROM 4-ACETOXY-2-PYRIDONES

DOI: 10.1016/S0040-4039(01)90019-X

Source and publish data:

Tetrahedron Letters p. 1591 - 1594 (1984)

Update date:2022-08-16

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Authors:

Kaneko, Chikara

Naito, Toshihiko

Saito, Akemi

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Article abstract of DOI:10.1016/S0040-4039(01)90019-X

4-(2'-Hydroxyethyl)azetidin-2-one, an important synthetic intermediate for carbapenem, and its substituted derivatives have been synthesized from 4-acetoxy-2-pyridones by photolysis, catalytic hydrogenation, followed by basic hydrolysis in the presence of sodium borohydride.

Full text of DOI:10.1016/S0040-4039(01)90019-X

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