Studies towards the synthesis of radiolabeled R106-1(LY295337)

DOI: 10.1002/(SICI)1099-1344(199611)38:11<979::AID-JLCR911>3.0.CO;2-T

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 979 - 987 (1996)

Update date:2022-08-11

Topics:

Authors:

Rodriguez, Michael J.

Zweifel, Mark J.

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Article abstract of DOI:10.1002/(SICI)1099-1344(199611)38:11<979::AID-JLCR911>3.0.CO;2-T

A unique semisynthetic pathway has been used as a route to acquire radiolabeled material of a complex natural product, R106. The retro-aldol reaction of R106-1 gave a key intermediate R106-sarcosine that was used in a subsequent aldol reaction to incorporate acetone-[2-¹⁴C].

Full text of DOI:10.1002/(SICI)1099-1344(199611)38:11<979::AID-JLCR911>3.0.CO;2-T

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