Two convenient new syntheses of ferrocenoyl chloride by triphosgene

Article abstract of DOI:10.1016/S0022-328X(00)00182-0

Two convenient new syntheses of ferrocenoyl chloride by triphosgene were reported. Firstly, ferrocenoyl chloride was conveniently prepared in 61.5% yield when triphosgene was reacted with ferrocene carboxylic acid in methylene dichloride at room temperature in the presence of triethylamine and DMAP. This new method for the synthesis of ferrocenoyl chloride enjoys a number of advantages in that the reaction is carried out under mild conditions and is cleaner without the formation of POCl₃, H₃PO₃ or SO₂ and dark-colored impurities. Secondly, ferrocene underwent reaction with one-third equivalent of triphosgene to give ferrocenoyl chloride in 38.1% yield. The main advantage of the second method for the synthesis of ferrocenoyl chloride is using cheap ferrocene as starting material.