Tetrahedron Letters p. 2663 - 2666 (1996)
Update date:2022-08-29
Topics:
Medarde, Manuel
Ramos, Angel C.
Caballero, Esther
Lopez, Jose Luis
Pelaez-Lamamie De Clairac, Rafael
San Feliciano, Arturo
A formal synthesis of podophyllotoxin has been achieved by means of the well known conjugate addition-alkylation of 5H-furan-2-one, followed by cyclization and controlled epimerizations. This approach represents a useful new route to the 8,7'-trans-stereo
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Doi:10.1002/anie.201703923
()Doi:10.3390/md17060333
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()Doi:10.1021/acscatal.0c04330
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