Atorvastatin, an HMG-CoA reductase inhibitor and efficient lipid-regulating agent. Part I. Synthesis of ring-labeled [14C]atorvastatin

Article abstract of DOI:10.1002/(SICI)1099-1344(199902)42:2<121::AID-JLCR173>3.0.CO;2-Z

Pyrrole-ring labeled [¹⁴C]atorvastatin (Lipitor, CI-981), [R-(R(*),R(*))]-2(4-fluorophenyl)-β,γ-dihydroxy-5-(1-methylethyl)-3-phenyl -4-[(phenylamino)-carbonyl]-1H-[3-¹⁴C]pyrrole-1-heptanoic acid calcium salt (2:1), was synthesized i