Solid-state reaction between sulfacetamide and phthalic anhydride by grinding

Article abstract of DOI:10.1248/cpb.42.1342

Sulfacetamide reacted with phthalic anhydride in the solid state and was gradually converted into phthalylsulfacetamide with mechanical grinding. Formation of phthalylsulfacetamide was confirmed by high pressure liquid chromatography and Fourier transform infrared spectroscopy. The X-ray diffraction pattern of ground powder of sulfacetamide and phthalic anhydride mixture (1:1 by molar ratio) gradually became a halo with the formation of phthalylsulfacetamide, indicating that amorphous phthalylsulfacetamide was obtained by the solid-state reaction with mechanical grinding. The solid- state reaction between sulfacetamide and phthalic anhydride also occurred when a mixture of the two was heated. Crystalline phthalylsulfacetamide was formed by the solid-state reaction with heating.

Full text of DOI:10.1248/cpb.42.1342

NII-Electronic Library Service

NII-Electronic Library Service

NII-Electronic Library Service