Synthesis of several 3-substituted 2-trifluoromethylindoles via Mannich reaction of 2-trifluoromethylindoles

DOI: 10.1248/cpb.45.932

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Chemical and Pharmaceutical Bulletin p. 932 - 935 (1997)

Update date:2022-08-24

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Authors:

Miyashita, Kazuyuki

Kondoh, Katsunori

Tsuchiya, Katsutoshi

Miyabe, Hideto

Imanishi, Takeshi

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Article abstract of DOI:10.1248/cpb.45.932

Several 2-trifluoromethyl derivatives of biologically active indoles, tryptamine, indole-3-acetic acid, oxypertine and tryptophan, were synthesized starting from 2-trifluoromethylindoles by use of the Mannich reaction and subsequent nucleophilic substitut

Full text of DOI:10.1248/cpb.45.932

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