Lactone Synthesis by Mn(III)-Mediated Oxidative Cyclization of Allylic β-Diesters

Article abstract of DOI:10.1021/jo00285a014

Oxidative free-radical cyclization of allylic β-diesters with Mn(OAc)3-Cu(OAc)2 leads to various γ-lactones resulting exclusively from a 5-exo cyclization.The products depend on the α substituent on the malonic ester, on the stereoselectivity of the intramolecular addition step, and on the nature of the intermediate radical.