5-hydroxypentane-2,3-dione and 3-amino-1-hydroxypropan-2-one, putative precursors of vitamin B6

Article abstract of DOI:10.1139/v97-113

New synthesis are described of 5-hydroxypentane-2,3-dione (7) (i.e., laurencione (7 ? 8)) and of 3-amino-1-hydroxypropan-2-one (3-amino-1- hydroxyacetone) (5) hydrochloride, putative precursors of the C₅ unit, C- 2',2,3,4,4', and of the C₃N unit, N-1,C-6,5,5', respectively, of pyridoxine (6). The condensation of hydroxypentane dione (i.e., laurencione) and aminohydroxypropanone forms a vitamin B, pyridoxine. The two compounds incorporated structural modifications on the formation mechanism of vitamin B. These compounds were considered as putative precursors of the C₅ unit and the C₃N unit of pyridoxine.