A novel kinetically-controlled peptide synthesis - Dramatic increase of chemical yield with retention of chiral integrity

Article abstract of DOI:10.1016/S0040-4039(99)01493-8

Peptide synthesis employing the highly selective reaction of isobutyl chloroformate at the carboxyl group of the N-protected amino acid, almost to the exclusion of the amino group of the C-protected amino acid, is described. This one-stage, kinetically-controlled strategy remarkably affords peptides with excellent optical purity in high chemical yields.