Stereospecific Synthesis of 4-Alkylglutamates and 4-Alkylprolines

Article abstract of DOI:10.1016/0040-4039(94)85381-9

Catalytic reduction of the 4-alkylidenepyroglutamate derivatives (3) affords an effective route to (2S,4S)-4-alkylglutamic acids and (2S,4S)-4-alkylprolines.The route has also been used to prepare a 4-alkylpyroglutamic acid derivative which is stereospeci