Influence of substituents of the mechanism of oxidation of amino acids

Article abstract of DOI:10.1016/S0040-4020(01)85523-X

The kinetics of oxidation of amino acids (AA) by peroxomonosulphate in aqueous alkaline medium at 35°C is studied. Based on the experimental results, a reaction scheme is proposed in which the electrophilic attack of HSO₅^- occurs at the amino nitrogen. The break down of the intermediate is influenced by the nature of the substituent at the amino carbon atom. The formation of imine/imino acid is supported by the absorption spectra of the intermediate.