Apparent proton-catalyzed Meerwein-Ponndorf-Verley type reduction of 8-chloro-6-(2-fluorophenyl)-1-methyl-6H-imidazo[1,5-a][1,4]benzodiazep ine

Article abstract of DOI:10.1016/S0040-4039(00)60952-8

When treated with 2-propanol in the presence of HCl, reduction of the C4-N double bond in 8 chloro-6-(2-fluorophenyl)-1-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin e occurs. Data are presented which indicate 2-propanol is the reductant in a two-step mechanism.