HYDROLYSIS IN THE ABSENCE OF BULK WATER 2. CHEMOSELECTIVE HYDROLYSIS OF NITRILES USING TETRAHALOPHTHALIC ACIDS

DOI: 10.1016/S0040-4039(00)82396-5

Source and publish data:

Tetrahedron Letters p. 6557 - 6560 (1988)

Update date:2022-08-11

Topics:

Authors:

Rounds, William D.

Eaton, Jefferson T.

Urbanowicz, John H.

Gribble, Gordon W.

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Article abstract of DOI:10.1016/S0040-4039(00)82396-5

The reaction of nitriles with tetrafluorophthalic or tetrachlorophthalic acid gives carboxylic acids in good yield.The reaction is chemoselective in that the nitrile functionality can be hydrolyzed in the presence of ester groups.

Full text of DOI:10.1016/S0040-4039(00)82396-5

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