Enzymatic acylation and alkoxycarbonylation of α-, xylo-, anhydro-, and arabino-nucleosides

Article abstract of DOI:10.1016/S0040-4020(01)80204-0

5'-O-acyl and 5'-O-alkoxycarbonyl derivatives of α-, anhydro-, xylo- and arabinonucleosides could be obtained through a lipase-mediated reaction with SP 435 lipase (from Candida antarctica) by using acetoxime butyrate or butyric anhydride, together with benzyloxycarbonyl-O-acetoxine as acylating agents. Alkoxycarbonylation gave poorer yields than acylation and other lipases tested gave non-selective reaction or not reaction at all.