Amide anions as unexpected activating groups in nucleophilic heteroaromatic substitution

DOI: 10.1016/0040-4039(96)00734-4

Source and publish data:

Tetrahedron Letters p. 4065 - 4068 (1996)

Update date:2022-08-16

Topics:

Authors:

Gillies Gillies

Gillies, Iain

Rees Rees

Rees, Charles W.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(96)00734-4

Nucleophilic displacement of halide by alkoxide in pyridazines, phthalazines, a thiazole and a thiadiazole is unexpectedly activated by acetamido anion substituents compared to neutral amido and amino substituents.

Full text of DOI:10.1016/0040-4039(96)00734-4

Products guided by the article

Product name:N-(6-Chloro-3-pyridazinyl)acetamide

Cas No:14959-31-0

R&D Labs maybe for 14959-31-0

Quzhou Aokai Chemical Co., Ltd.

Contact:86-570-3032832

Address:NO.16 , Laodong Road,Quzhou City, Zhejiang Province,China
CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD

website:http://www.czyys.com

Contact:0086-519-88802789

Address:No.300,Yanling Middle Road, Changzhou, Jiangsu, China
BAODING SINO-CHEM INDUSTRY CO.,LTD

Contact:0312-5956088

Address:NO.8 FUXING ROAD,CHINA
Mashilabs(shanghai)Co.,ltd

Contact:+86-21-54391580

Address:Room 502,No.65,Lane 2388 Hongxin Road,Shanghai,China
Shijiazhuang Haitian Amino Acid Co., Ltd.

Contact:+86-311-88908111

Address:Shijiazhuang Hebei province,China

Relevant to this article

Doi:10.1039/JR9510001438
()
Short-Chained Anthracene Strapped Porphyrins and their Endoperoxides

Doi:10.1002/ejoc.202000283
(2020)
Synthesis and reaction of unsymmetrical tetraarylbismuthonium salts. First isolation of bismuthonium salts bearing all different aryl groups

Doi:10.1246/cl.1998.127
(1998)
Doi:10.1021/ja01176a501
(1949)
Reductive biotransformation of 3-oxo bile acids in human blood

Doi:10.1248/cpb.37.1960
(1989)
Synthesis and structure of thienyl Fischer carbene complexes of Pt^IIfor application in alkyne hydrosilylation

Doi:10.1039/d1nj00791b
(2021)

Article Doi