A concise total synthesis of (+)-curacin A, a novel cyclopropyl- substituted thiazoline from the cyanobacterium Lyngbya majuscula

Article abstract of DOI:10.1016/S0040-4039(98)00318-9

A total synthesis of (+)-curacin A 1 which features a facile and selective thioacylation of the polyene amino-alcohol 2 with the benzotriazole-derived cyclopropyl thioamide 3, leading to 15, as a key step is described.