Inhibition of 5-α-reductase (type-II) expression by antisense 3'- deoxy-(2'-5') oligonucleotide chimeras

Article abstract of DOI:10.1080/07328319708006156

3'-Deoxy-(2'-5') oligonucleotides bind selectively to complementary RNA but not to DNA. 3'-Deoxy-(2'-5') phosphorothioate ODN chimeras embedded with a short stretch of 3'-5' phosphorothioate cassette are potent inhibitors of steroid 5-α-reductase expression with significantly less non-specific interactions in cell culture.

Full text of DOI:10.1080/07328319708006156

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Nucleosides and Nucleotides
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Inhibition of 5-α-Reductase (TYPE-
II) Expression by Antisense 3′-Deoxy-
(2′-5′) Oligonucleotide Chimeras
Purshotam Bhan a , Anila Bhan a , Mikung Hong a , John G.
Hartwell a , June M. Saunders a & Glenn D. Hoke a
a Dyad Pharmaceutical Corporation , 9110 Red Branch Road,
Columbia, Maryland, 21045, USA
Published online: 16 Aug 2006.
To cite this article: Purshotam Bhan , Anila Bhan , Mikung Hong , John G. Hartwell , June M.
Saunders & Glenn D. Hoke (1997) Inhibition of 5-α-Reductase (TYPE-II) Expression by Antisense
3′-Deoxy-(2′-5′) Oligonucleotide Chimeras, Nucleosides and Nucleotides, 16:7-9, 1195-1199, DOI:
10.1080/07328319708006156
To link to this article: http://dx.doi.org/10.1080/07328319708006156
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