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Complestatin to chloropeptin I via a quantitative acid catalyzed rearrangement. Absolute stereochemical determination of complestatin

DOI: 10.1016/S0040-4039(98)00270-6

Source and publish data:

Tetrahedron Letters p. 2247 - 2248 (1998)

Update date:2022-08-10

Topics:

Authors:

Jayasuriya, HiranthiJayasuriya, Hiranthi

Salituro, Gino M.Salituro, Gino M.

Smith, Scott K.Smith, Scott K.

Heck, James V.Heck, James V.

Gould, Steven J.Gould, Steven J.

Singh, Sheo B.Singh, Sheo B.

Homnick, Carl F.Homnick, Carl F.

Holloway, M. KatharineHolloway, M. Katharine

Pitzenberger, Steven M.Pitzenberger, Steven M.

Patane, Michael A.Patane, Michael A.

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Article abstract of DOI:10.1016/S0040-4039(98)00270-6

Complestatin and isomeric chloropeptin I are bicyclo hexapeptides isolated from a Streptomyces sp. Both of these compounds are inhibitors of gp120-CD4 HIV fusion activity. In this paper, we describe an efficient acid catalyzed conversion of complestatin t

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Full text of DOI:10.1016/S0040-4039(98)00270-6

Products guided by the article

Product name:Glycine,N-[2-(3,5-dichloro-4-hydroxyphenyl)-2-oxoacetyl]-D-alanyl-(2R)-2-(3,5-dichloro-4-hydroxyphenyl)glycyl-(2R)-2-(3,4-dihydroxyphenyl)glycyl-(2R)-2-(3,5-dichloro-4-hydroxyphenyl)glycyl-N-methyl-L-tyrosyl-2-(4-hydroxyphenyl)-,cyclic (33®5)-ether, cyclic13,35-(1H-indole-3,7-diyl) deriv., (2R)-

Cas No:160219-64-7

160219-64-7

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