Tetrahedron Letters p. 1045 - 1048 (1999)
Update date:2022-08-11
Topics:
Cobb, James M.
Fiorini, Maria T.
Goddard, Chris R.
Theoclitou, Maria-Elena
Abell, Chris
A decarboxylative traceless linker strategy for the cleavage of resin- bound quinazolines has been developed using hydroxymethylpolystyrene (HMPS) resin derivatised as the ethyl oxalate. Methods for the solid phase synthesis of the linker, quinazoline formation, functionalisation and cleavage are described.
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