A decarboxylative traceless linker approach for the solid phase synthesis of quinazolines

Article abstract of DOI:10.1016/S0040-4039(99)80108-7

A decarboxylative traceless linker strategy for the cleavage of resin- bound quinazolines has been developed using hydroxymethylpolystyrene (HMPS) resin derivatised as the ethyl oxalate. Methods for the solid phase synthesis of the linker, quinazoline formation, functionalisation and cleavage are described.