An efficient synthesis of (±)-4-amino-3-(4-chlorophenyl)-butyric acid. (baclofen)

Article abstract of DOI:10.1080/00397919508015419

A new preparation of baclofen is proposed. The key step involved a regioselective ring opening of 2-phenylaziridine with allylmagnesium bromide. Further oxidation of the side chain gives access to 4-phenyl-pyrrolidin-2-one and to baclofen.

Full text of DOI:10.1080/00397919508015419

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An Efficient Synthesis of (±)-4-
Amino-3-(4-chlorophenyl)-
butyric Acid. (Baclofen)
Toshiro Ibuka a , An[ggrave]ele Schoenfelder b ,
Patricia Bildstein a & Andre Mann b
a Faculty of Pharmaceutical Sciences, Kyoto
University, Kyoto, 606, Japan
b Laboratoire de Pharmacochimie Moléculaire (UPR
421), Centre de Neurochimie, 5, rue Blaise Pascal,
67084, Strasbourg, France
Published online: 23 Sep 2006.
To cite this article: Toshiro Ibuka , An[ggrave]ele Schoenfelder , Patricia Bildstein &
Andre Mann (1995): An Efficient Synthesis of (±)-4-Amino-3-(4-chlorophenyl)-butyric
Acid. (Baclofen), Synthetic Communications: An International Journal for Rapid
Communication of Synthetic Organic Chemistry, 25:12, 1777-1782
To link to this article: http://dx.doi.org/10.1080/00397919508015419
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