Tetrahedron Asymmetry p. 1275 - 1278 (1997)
Update date:2022-08-10
Topics:
Doller, Dario
Davies, Robert
Chackalamannil, Samuel
The resolution of (±)-2-methylpiperidine using D- and L-tartaric acid followed by direct conversion of the intermediate tartrate salts to (R) and (S)-N-Boc-2-methylpiperidine is described. Also described is an NMR protocol for assessing the optical purity of the intermediate tartrate salts as well as the free bases. The resolved enantiomers showed an ee of >98% based on NMR integration.
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