Esters of 4 [3 [2 (trifluoromethyl)phenothiazin 10 yl]propyl] 1 piperazineethanol and related compounds as long acting antipsychotic agents. Synthesis of the 1 adamantoate, the first crystalline base. 4

Article abstract of DOI:10.1021/jm00212a023

A number of new esters of fluphenazine are described; among these was the 1 adamantoate, 1h, the first highly crystalline ester of that drug. The 1 adamantoate of pipotiazine, 2b, typically, was an oil. Following a single subcutaneous or intramuscular injection of 25 mg/kg of either 1h or 2b, dissolved in sesame oil, each ester was found to be a potent and long acting inhibitor of conditioned avoidance behavior in the rat.