Attempted synthesis of a Tenidap isomer and formation of an unexpected stable water adduct

Article abstract of DOI:10.1002/jhet.5570370441

An attempt to synthesize the Tenidap isomer 13 was performed starting from 2-ethoxy-5-chloroindole (9). The acylation and carbamoylation reactions of 9 led to the expected intermediate 12, however the hydrolysis of 12 in acidic or alkaline media did not y