2-Alkyl-substituted histamines and hydroxyethylimidazoles with G-protein-stimulatory activity

Article abstract of DOI:10.1016/0223-5234(96)89166-5

Cationic-amphiphilic 2-substituted histamines activate pertussis toxin-sensitive guanine nucleotide-binding proteins (G-proteins) by a receptor-independent mechanism. From our recent studies it became apparent that lipophilicity is an important determinan