The synthesis of phosphinic acid based proteinase inhibitors

Article abstract of DOI:10.1080/10426509908546356

The phenyl phosphinate analogues of valine and phenylalanine with extended chains at phosphorus have been prepared as racemic mixtures and also in high optical purity. Kinetic data clearly indicate specific inhibitory activity for analogues having (R) configuration at α-carbon. A similar synthetic approach provides a simplified route to reported C₂ symmetrical HIV inhibitors.

Full text of DOI:10.1080/10426509908546356

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Phosphorus, Sulfur, and
Silicon and the Related
Elements
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The Synthesis of
Phosphinic Acid Based
Proteinase Inhibitors
Robert Hamilton , Scott Wharry , Brian
Walker & Brian J. Walker
a School of Chemistry and The Queen's
University of Belfast , Belfast, BT9 5AG,
N. Ireland., U.K.
b School of Chemistry and The Queen's
University of Belfast , Belfast, BT9 5AG,
N. Ireland., U.K.
c School of Chemistry and The Queen's
University of Belfast , Belfast, BT9 5AG,
N. Ireland., U.K.
d School of Chemistry and The Queen's
University of Belfast , Belfast, BT9 5AG,
N. Ireland., U.K.
Published online: 17 Mar 2008.
To cite this article: Robert Hamilton , Scott Wharry , Brian Walker &
Brian J. Walker (1999) The Synthesis of Phosphinic Acid Based Proteinase
Inhibitors, Phosphorus, Sulfur, and Silicon and the Related Elements,
144:1, 761-764, DOI: 10.1080/10426509908546356

To link to this article: http://dx.doi.org/10.1080/10426509908546356
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