Rhodopeptins, novel cyclic tetrapeptides with antifungal activities from Rhodococcus sp.. II. Structure elucidation

Article abstract of DOI:10.7164/antibiotics.52.700

The structures of rhodopeptins, novel antifungal peptides, were determined on the basis of physico-chemical analyses of the intact molecules and their acid hydrolysates. The structures of rhodopeptins C1, C2, C3, C4 and B5 were determined to be cyclo (-Gly-L-Orn-L-Val-3-amino-10 -methyldodecanoyl-), cyclo (-Gly-L-Orn-L-Ile-3-amino-10-methyldodecanoyl-), cyclo (-Gly-L-Orn-L-Val-3 -amino-12-methyltridecanoyl-), cyclo (-Gly-L-Orn-L-Val-3-amino-l2-methyltetradecanoyl-) and cyclo (-Gly-L-Lys-L-Val-3-amino-13-methyltetradecanoyl-), respectively. They are novel cyclic tetrapeptides containing a lipophilic β-amino acid.