Micro Chlorination Procedure for Synthesis of Higher Chlorinated Dibenzo-p-dioxins from -2,3,7,8-Tetrachlorodibenzo-p-dioxin

Article abstract of DOI:10.1021/ac00240a013

An efficient microscale chlorination procedure termed "surface chlorination" is described.By use of this technique with a silica supporting matrix, 7.4 μg of <13C>-2,3,7,8-tetrachlorodibenzo-p-dioxin is converted to <13C>-octachlorodibenzo-p-dioxin in cca 60 min at 100 deg C.Following liquid chromatography product purification and identification and confirmation of component identity using instrumental techniques, an 80percent yield is achieved.The unique advantages and other possible applications of this reaction matrix are also discussed.