Kilogram scale synthesis of the pyrazinone acetic acid core of an orally efficacious thrombin inhibitor

Article abstract of DOI:10.1080/00397910008086927

A multi-kilogram scale synthesis of the orally efficacious thrombin inhibitor 1 has been achieved via construction of the pyrazinone core from an unsymmetric oxalic diamide. Key features include judicious choice of reagents to minimize side products, a ke

Full text of DOI:10.1080/00397910008086927

Synthetic Communications
ISSN: 0039-7911 (Print) 1532-2432 (Online) Journal homepage: http://www.tandfonline.com/loi/lsyc20
Kilogram Scale Synthesis of the Pyrazinone Acetic
Acid Core of an Orally Efficacious Thrombin
Inhibitor
Fred J. Fleitz , Terry A. Lyle , Nan Zheng , Joseph D. Armstrong III & R. P.
Volante
To cite this article: Fred J. Fleitz , Terry A. Lyle , Nan Zheng , Joseph D. Armstrong III &
R. P. Volante (2000) Kilogram Scale Synthesis of the Pyrazinone Acetic Acid Core of an
Orally Efficacious Thrombin Inhibitor, Synthetic Communications, 30:17, 3171-3180, DOI:
10.1080/00397910008086927
To link to this article: http://dx.doi.org/10.1080/00397910008086927
Published online: 04 Dec 2007.
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Date: 17 November 2015, At: 17:31