Chiral phosphinooxazolines with a Bi- or tricyclic oxazoline moiety - Applications in Pd-catalyzed allylic alkylations

Article abstract of DOI:10.1016/S0040-4039(98)01173-3

Phosphinooxazolines with a bi- or tricyclic oxazoline moiety are described. In Pd-catalyzed alkylations of 1,3-dimethylallyl acetate with sodium dimethyl malonate enantiomeric excess of up to 89.5 % was obtained. This is the best result so far achieved for this substrate with P,N-chelate ligands.