Bioorganic and Medicinal Chemistry p. 557 - 562 (1996)
Update date:2022-08-25
Topics:
Boschelli, Diane H.
Connor, David T.
Lesch, Mark E.
Schrier, Denis J.
The surface levels of ICAM-1 and E-selectin on activated endothelial cells can be reduced by 3-alkoxybenzo[b]thiophene-2-carboxamides. This property is shared by several N-alkylthiopyridine substituted imides. Combining structural elements of these two diverse series lead to a new class of small molecule inhibitors of adhesion molecule expression.
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