Polymer-supported acylhydrazones. Use in Sc(OTf)3-catalyzed mannich- type reactions providing an efficient method for the preparation of diverse pyrazolone derivatives

DOI: 10.1016/S0040-4039(98)02607-0

Source and publish data:

Tetrahedron Letters p. 1341 - 1344 (1999)

Update date:2022-08-12

Topics:

Authors:

Kobayashi

Furuta Furuta

Sugita Sugita

Okitsu Okitsu

Oyamada Oyamada

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Article abstract of DOI:10.1016/S0040-4039(98)02607-0

Polymer-supported acylhydrazones, prepared from polystyrene resin (1%divinylbenzene), reacted with ketene silyl acetals in the presence of a catalytic amount of scandium triflate (Sc(OTf)₃), to afford the corresponding β-hydrazinoesters, which were cyclized and cleaved from the support simultaneously by treatment with a base to produce diverse pyrazolone derivatives.

Full text of DOI:10.1016/S0040-4039(98)02607-0

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