Antimicrobial steroids from the fungus Fomitopsis pinicola

Article abstract of DOI:10.1016/0031-9422(95)00762-8

Phytochemical examination of the dichloromethane extract of the European fungus Fomitopsis pinicola led to the isolation of a new lanostanoid derivative identified from spectral and chemical evidences as 3α-(4-carboxymethyl-3-hydroxy-3-methylbutanoyloxy)-lanosta-8,24-dien-21- oic acid. In addition, seven known triterpenes, polyporenic acid C, 3α-acetyloxylanosta-8,24-dien-21-oic acid, ergosta-7,22-dien-3β-ol, 21-hydroxylanosta-8,24-dien-3-one, pinicolic acid A, trametenolic acid B and pachymic acid, were also isolated. Antimicrobial activity against Bacillus subtilis in a TLC bioassay was observed for five of the isolated steroids. Copyright