A chemoselective rhodium(II) mediated solid phase 1,3-dipolar cycloaddition and its application to a thermally self-cleaving puran scaffold

Article abstract of DOI:10.1016/S0040-4039(97)01768-1

A chemoselective rhodium(II) mediated 1,3-dipolar cycloaddition reaction on solid-phase for the construction of a template-directed scaffold is described. In this paper, the reaction of acetylenes with isomunchnones is presented as a general methodology for the combinatorial formation of a furan based library. Additionally, through (he development of a novel thermolytic cleavage step, this furan synthesis yields pure product from the solid-phase in a temperature dependent manner.