
Bulletin of the Chemical Society of Japan p. 3306 - 3307 (1983)
Update date:2022-08-11
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In the alkylation of phenylacetonitrile with alkyl halides, alkali metal hydroxides impregnated on alumina act as efficient bases for selective alpha -monoalkylation in benzene. It is proposed that the reaction may take place exclusively in the pore. The selectivity for alpha -monoalkylation is explained in terms of steric hindrance.
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(1942)