Chemical Biology and Drug Design p. 699 - 709 (2016)
Update date:2022-08-17
Topics:
Luo, Jian
Yang, Qiu-E
Yang, Yuan-Yuan
Tang, You-Zhi
Liu, Ya-Hong
A series of novel pleuromutilin derivatives possessing piperazine moieties were synthesized under mild conditions. The in vitro antibacterial activities of these derivatives against Staphylococcus aureus and Escherichia coli were tested by the agar dilution method. Structure–activity relationship studies resulted in compounds 11b, 13b, and 14a with the most potent in vitro antibacterial activity among the series (minimal inhibitory concentration?=?0.0625–0.125?μg/mL). The binding of compounds 11b, 13b, and 14a to the E.?coli ribosome was investigated by molecular modeling, and it was found that there is a reasonable correlation between the binding free energy and the antibacterial activity.
View MoreContact:+86-571-28186845
Address:Room 1224,Eastcom Mansion,398 Wensan Road,Hangzhou,310013 China
Changzhou LanXu Chemical Co.,ltd.
Contact:86-0519-86330911,13656129734,15261186386
Address:Room 524, Depart.Chemical, Changzhou Science and Eductaion town, Jiangsu, China;Factory: Haian Fine Chemical Industry Park,Nantong,Jiangsu,China
Chengdu ZY Biochemical Technology Co., LTD
Contact:0086-28-88680086
Address:170 Qingpu Road, Shouan Town, Pujiang County
SuZhou Bichal Biological Technology CO.,LTD
Contact:+86-512-68051130
Address:NO.32 huoju road HI-TECH Industrial development zone SuZhou China
Hubei Xinjing New Material Co.,Ltd
Contact:+86-27-83313147
Address:Room402.#Bthe 7th,Headquarter of Huifeng Corporation Qiaokou District,Wuhan China
Doi:10.1016/0040-4020(95)00038-A
(1995)Doi:10.1016/S0040-4039(01)01148-0
(2001)Doi:10.1007/BF00356053
()Doi:10.1021/jo00431a042
(1977)Doi:10.1080/14786419.2013.805331
(2013)Doi:10.1055/s-2006-951512
(2006)