Bioorganic and Medicinal Chemistry Letters p. 2008 - 2012 (2006)
Update date:2022-08-10
Topics:
Huscroft, Ian T.
Carlson, Emma J.
Chicchi, Gary G.
Kurtz, Marc M.
London, Clare
Raubo, Piotr
Wheeldon, Alan
Kulagowski, Janusz J.
1-Phenyl-8-azabicyclo[3.2.1]octane ethers are NK1 receptor antagonists. Substitution at the 6-exo-position led to high affinity NK 1 antagonists with a prolonged duration of action in vivo. Incorporation of an α-methyl substituent in
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