Asymmetric synthesis XXV: Enantioselective synthesis of ethyl β-hydroxy-β-phenyl propanoate via an asymmetric Reformatsky reaction

Article abstract of DOI:10.1016/0957-4166(95)00345-P

Both stoichiometric and catalytic amounts of N,N-dialkyl derivatives of D or L-1,2-diphenyl aminoalcohols were used as chiral ligands in the enantioselective Reformatsky reaction of benzaldehyde with ethyl bromoacetate at reflux in the presence of Zn-Cu c