Hydroxyphenyl-1-methylpyridinium-iodide as Potential Reactivators of Acetylcholinesterase Poisoned with Organophosphorus Compounds

DOI: 10.1002/hlca.19830660406

Source and publish data:

Helvetica Chimica Acta p. 1039 - 1045 (1983)

Update date:2022-08-11

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Authors:

Riggio, Gaetano

Hopff, Wolfgang Herbert

Hofmann, Alfred Andre

Waser, Peter Gaudenz

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Article abstract of DOI:10.1002/hlca.19830660406

It was our aim to reactivate acetylcholinesterase poisoned with sarin.We synthesized 2-(o-hydroxyphenyl)-1-methylpyridinium-iodide (9), 2-(p-hydroxyphenyl)-1-methylpyridinium-iodide (19) and 4-(o-hydroxyphenyl)-1-methylpyridinium-iodide (14) as potential reactivators.All substances showed moderate toxicity against mice; their reactivity potency in vitro and in vivo was negligible.

Full text of DOI:10.1002/hlca.19830660406

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