Hemiaminals of trifluoroacetaldehyde, as trifluoromethylating agents

DOI: 10.1016/S0040-4039(99)01369-6

Source and publish data:

Tetrahedron Letters p. 6411 - 6414 (1999)

Update date:2022-08-11

Topics:

Authors:

Mispelaere, Clotilde

Roques, Nicolas

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Article abstract of DOI:10.1016/S0040-4039(99)01369-6

Hemiaminals of trifluoroacetaldehyde are new trifluoromethylating agents. These reagents are synthesised from amines and gaseous trifluoroacetaldehyde. tBuONa is able to deprotonate the hemiaminals to form trifluoromethyl anion equivalents CF₃CH(O^-)NMe₂. The trifluoromethyl anion has been transferred from such intermediates to benzaldehyde yielding phenyl (trifluoromethyl) methanol.

Full text of DOI:10.1016/S0040-4039(99)01369-6

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