A novel highly effective chiral lithium amide for catalytic enantioselective deprotonation of meso-epoxides

Article abstract of DOI:10.1016/S0040-4039(97)01487-1

A highly enantioselective deprotonation of meso-epoxides was achieved by a catalytic amount of a new chiral lithium amide, derived from (2S,3aS,7aS)-2-(pyrrolidin-1-ylmethyl)octahydroindole, in the presence of excess lithium diisopropylamide to afford the corresponding allylic alcohol derivatives up to 94% ee.